dihexa derived from angiotensin iv Dihexa - CAS# 1401708-83-5. CAS#

However, there are now several selective -opioid receptor agonists available, including peptides such as DPDPE and deltorphin II, and non-peptide drugs such as SNC-80, [23] the more potent (+)-BW373U86, [24] a newer drug DPI-287, which does not produce the problems with convulsions seen with the earlier agents, [25] and the mixed / agonist DPI-3290, which is a much more potent analgesic than the more highly selective agonists

Prog Neuropsychopharmacol Biol Psychiatry 35, 10221025 (2011)

Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable

This reflects the PK-PD disconnect the biological effects triggered by the peptide persist beyond the peptide itself