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Mechanistically, curcumin reduces local inflammation, oxidative stress, and immune dysregulation around ulcers

14,15-EET inhibited rat mesenteric arterial endothelial senescence, down-regulated p53 expression in aged endothelial cells and improved the impaired endothelium-dependent vasodilatation in aged rats through activation of mTORC2/Akt signaling pathway (Yang et al., 2014)

Redox repair of the oxidised forms (ergothioneine disulfide and 5-oxo-ergothioneine) of ergothioneine can be rapidly provided by ascorbate (Reference Asmus, Bensasson and Bernier48) or can be achieved enzymatically by either glutathione reductase in presence of glutathione, or the selenoenzyme thioredoxin reductase (Reference Jenny, Mose and Haupt50)