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We enrolled laboratory-confirmed COVID-19 patients aged 18 years old whose imaging showed characteristic manifestations of COVID-19 pneumonia from December 2022 to January 2023

Common aneuploidies include trisomy of chromosome 8 and monosomy of chromosomes 5 and 7.3435 The phenolic metabolites of benzene have been shown to induce trisomy 8 and monosomy 5 and 7 in cultured human cells in vitro , including CD34 + progenitor cells.363738 Workers exposed to benzene also have higher levels of these aneuploidies in their peripheral blood.39 Through their inhibitory action on topoisomerase II, binding to other DNA-associated proteins and formation of DNA adducts, phenol and hydroquinone cause double-strand breaks and chromosome breakage.4041 This has been shown in vitro to lead to deletions and translocations commonly found in leukemia, including del(5q) and del(7q).38 Again, workers exposed to benzene have been shown to have higher levels of del(5q), del(7q) and translocation (8;21) in their blood cells.3942 Mice treated with phenol and hydroquinone also show elevated levels of aneuploidy and chromosome breakage in their bone marrow.26 Hydroquinone produces epigenetic changes that increase the risk of developing leukemia Other research has focused on the possible epigenetic mechanisms involved in benzene-induced leukemia

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