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These ethnomedicinal uses are supported by the scientific evidence gathered in this review, which reveals a rich phytochemical composition of the leaves, including phenolic compounds, flavonoids and triterpenes, known for their antioxidant, anti-inflammatory, antimicrobial and antidiabetic properties

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[116] This natural increase suggests that melatonin plays important physiological roles during pregnancy, including potential effects on fetal development, maternal circadian rhythms, and pregnancy outcomes

it is a statement that the systemic route removes the safety margin that topical use provides for anyone whose copper regulation is compromised