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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Hothorn M., Wachter A., Gromes R., Stuwe T., Rausch T., Scheffzek K

Abstract Rapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinsons disease (PD), affecting 4050% of PD patients

We cannot completely rule out the effect of recreational substances on the observed results (see Supplementary)