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Astrocytes are also deemed essential to the maturation, maintenance, and regulation of the BBB in the healthy brain [127]

MTHFR mutations can lead to vitamin B12, B6, and folate deficiencies and increased homocysteine levels in the body

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The clearance of the racemate in normal subjects, elderly individuals and in hepatically and renally impaired patients is outlined in Table 2 (see CLINICAL PHARMACOLOGY - Kinetics in Special Populations)