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Subsequently, M2 macrophages, which exhibit anti-inflammatory and repair characteristics, release growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), IGF-1 and TGF- to promote tissue repair (74)

This prevents the binding of fibrin to plasmin and preserves and stabilizes the matrix structure of fibrin and diminishes the ability of plasmin to lyse fibrin clots