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In treating neurodegenerative diseases such as AD, some studies developed NPs to deliver BACE1 siRNA to reduce A production and slowed disease progression, such as angiopep-2 peptides modified exosome-liposome hybrid nanovesicles loaded with BACE1 siRNA and TREM2 plasmid, 145 phosphatidic acid-functionalized high-density lipoprotein (pHDL) nanoscavengers loaded with curcumin and BACE1 siRNA (Figure 4A), 146 and dendrigraft poly-l-lysine (DGL)-based NPs co-loaded with BACE1 siRNA and rapamycin

p53 can promote SAT1 gene regulation at the transcriptional level, which induces lipid peroxidation and ferroptosis

their loss can severely impair oocyte development (120)

Neuropsychological deficits in patients with cognitive complaints after COVID-19