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Stimulation of the Cardionomic circuit begins when stress begins

[28] reported that in early Th17 differentiation, H3K4me1 is deposited at Th17-related gene regulatory regions by specific histone methyltransferases, priming enhancers for subsequent binding by RORt

Smad3 occupancy at specific DNA loci (COL1A1 and ADAMTSL2) in TGF-treated LX-2 cells was assessed using chromatin immunoprecipitation sequencing (ChIP-seq) data from public datasets