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Vagus nerve stimulation Considering that stimulation of the left vagus nerve has a minimal impact on heart rate and cardiac function [27], this study chose the left cervical vagus nerve trunk as the stimulation target

Numerous studies have shown that Nrf2 activation can effectively suppress the NF-B signalling pathway, thereby hindering the activation of inflammatory factors, mitigating the inflammatory response, and influencing the onset and progression of RA [112,113,114]