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The addition of GIP receptor activation in Retatrutide appears to improve tolerability rather than worsen it, which is consistent with what was observed in the shift from Semaglutide to Tirzepatide

Patients rotate injection sites daily to avoid localized tissue irritation

If any side effect appears during treatment, immediate cessation can prevent it

As a medication, we applied BPC 157 (10 g/kg, 10 ng/kg), L-NAME (5 mg/kg), L-arginine (100 mg/kg) alone and/or combined, intravenously, immediately after intravenous heparin administration, while controls received simultaneously an equivolume of saline (0.5 ml/kg intravenously)