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In agreement with this, we observed significantly decreased levels of choline, and alterations in the metabolites of both branches of the Kennedy pathway (phosphocholine, CDP-choline, phosphoethanolamine, CDP-ethanolamine)

doi: 10.1097/01.prs.0000162160.26682.6e

It has been observed that Polo-like kinase 1 (PLK 1) is suppressed in septic rats, leading to reduced expression of IB- and enhanced nuclear translocation of NF-B p65