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Immune Modulation at the Maternal-Fetal Interface Research has demonstrated that hCG modulates immune responses at the maternal-fetal interface through epigenetic mechanisms specifically, hCG inhibits CXCL10 expression in human endometrial stromal cells by enhancing EZH2 expression and inducing H3K27me3 histone methylation at the CXCL10 promoter, thereby suppressing T cell recruitment to the implantation site