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Description

By blocking the phosphorylation of Smad proteins, stachydrine reduces the expression of pro-fibrotic genes, thus diminishing the fibrotic response

Gamma-glutamyltransferase Gamma-glutamyltransferase (also -glutamyltransferase , GGT , gamma-GT , gamma-glutamyl transpeptidase

Based on this, we previously proposed that the AP2-driven clustering of LRP6 could be an avidity-boosting device that facilitates mutual assembly of signalosome components 11

Its unique mechanism, hypothesized to involve direct DNA interaction rather than surface receptor binding, sets it apart from other bioregulator peptides