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Abbreviations AEA: Anandamide ATF4: Activating transcription factor 4 BAI: Beck anxiety inventory BBB: Blood brain barrier BMC: Biomolecular condensate CBD: Cannabidiol ClinRO: Clinician-reported outcome CNS: Central nervous system CSSS: Chalfont seizure severity scale CXCL-16: C-X-C motif chemokine 16 CYP450: Cytochrome P450 enzyme system DDIT3: DNA damage inducible transcript 3 DIT: Dose-intense temozolomide DNA: Deoxyribonucleic acid EORTC: European organisation for research and treatment of cancer EPR: Enhanced permeability and retention ER: Endoplasmic reticulum FAAH: Fatty acid amide hydrolase FDA: Food and drug administration GBM: Glioblastoma multiforme GSC: Glioma stem cell HIF-1: Hypoxia-inducible factor-1 HSP: Heat shock protein IDO: Indoleamine 2,3-Dioxygenase JNK1/2: C-Jun N-terminal Kinase 1 and 2 LOX: Lipoxygenase LNC: Lipid Nanocapsule MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemotactic protein-1 MGMT: O6-Methylguanine-DNA Methyltransferase MMP-9: Matrix Metalloproteinase-9 MSC: Mesenchymal stem cell MTOR: Mammalian target of rapamycin NCI-CTCAE: National cancer institute-common terminology criteria for adverse events NLC: Nanostructured lipid carrier NRS: Numeric rating scale NSCs: Neural stem cells OASIS: Overall anxiety severity and impairment scale OS: Overall survival OTC: Over-the-counter PCL/PVA: Polycaprolactone/polyvinyl alcohol PDGF-AA: Platelet-derived growth factor-AA PFS6: 6-Month progression-free survival PI3K: Phosphoinositide 3-Kinase PKC : Protein Kinase C PLGA: Poly-lactic-co-glycolic acid P-gp: P-glycoprotein PRO: Patient-reported outcome PSQI: Pittsburgh sleep quality index PTEN: Phosphatase and tensin homolog QoL: Quality of life RELA: V-rel reticuloendotheliosis viral oncogene homolog A RNA: Ribonucleic acid ROS: Reactive oxygen species RR: Response rate Ser-PAI-1: SerpinE1-plasminogen activator inhibitor type-1 SGs: Stress granules SLN: Solid lipid nanoparticle STAT3: Signal transducer and activator of transcription 3 TGF-1: Transforming growth factor-1 THC: Tetrahydrocannabinol TIMP1/4: Tissue inhibitors of metalloproteinase 1 and 4 TMZ: Temozolomide TRIB3: Tribbles Pseudokinase 3 TRPV2: Transient receptor potential Vanilloid 2 TRPV4: Transient receptor potential Vanilloid 4 TTP: Time to progression uPA: Urokinase plasminogen activator VDAC1: Voltage-dependent anion channel 1 VEGF: Vascular endothelial growth factor WHO: World Health Organization References Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, et al

Humans excrete more MMA on the average than other species, and this suggests that humans may be poorer methylators of inorganic arsenic

these findings are is consistent with the results of the present study