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The underlying mechanisms also include altering the composition and balance of the gut microbiome, which further influence the process of neurodegeneration via the gut-brain axis (Fig

Freeze-thaw cycles are particularly destructive and should be absolutely avoided

Extensive empirical evidence indicates that deficiencies in vitamin D, B vitamins, and other micronutrients are linked to an increased incidence of depression (4, 5), especially among women and overweight older adults (6)

It has been reported that the consumption of LC can present some positive effects on healthy subjects by improving physical, mental, and cognitive functions, and also decreasing the feeling of fatigue in the elderly