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NAD+ activates sirtuins (particularly SIRT1 and SIRT3), which are NAD-dependent deacetylases that directly suppress NF-kB transcriptional activity

24 : 94149423 Loeffler M, Daugas E, Susin SA, Zamzami N, Metivier D, Nieminen AL, Brothers G, Penninger JM and Kroemer G (2001) Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor