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An F1-targeted mouse was bred with a tissue-specific Camk2a-Cre deletion mouse to generate F2

10.1093/schbul/sbs050 184 VrtikaP.SanderD.AndersonB.BadoudD.EliezS.DebbanM

doi:10.1001/jama.2015.3474 Tompkins DA, Bigelow GE, Harrison JA, Johnson RE, Fudala PJ, Strain EC

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia