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Several studies reported that CD4 + Th1/Th17 cells migrated from the peripheral to CNS through cytokine gradient and showed strong reactivity with the MS-associated myelin antigen in MS patients ( + T-cells with Th1 phenotype against EBNA-1 C-terminal spanning amino acids 400-641 ( MS is associated with three HLA class II alleles belonging to haplotype HLA-DR2 (DR2) ( + T-cells through the interaction of CD4 + TCR and MHC-II peptide complex, leading to signal transduction, activation, and differentiation of T-cells into different phenotypes ( Another study on T-cell repertoire in MS patients, including identical twins, found more EBV-specific T-cell repertoire in MS patients than in healthy individuals ( 2.4 B-cells in MS Although cross-reactive T-cell-dominated inflammation is a characteristic of almost all types lesions, the presence of EBNA-1-specific autoantibodies has also been observed in the CNS of MS patients ( 2.5 Crosstalk between B and T-cells in MS B-cells are multifunctional players in mediating both humoral and cellular immune responses

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(2011) demonstrated BPC-157 stimulates fibroblast and tenocyte migration through FAK-Paxillin activation