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Description

Concretely, EC-derived lactate induces histone Kla, particularly H3K18la, which promotes the differentiation of bone mesenchymal stem cells (BMSCs) into osteoblasts by activating osteogenic genes such as COL1A2, COMP, ENPP1, and TCF7L2

Blanco-Grau A, Gabriel-Medina P, Rodriguez-Algarra F, Villena Y, Lopez-Martnez R, Augustn S, Pons M, Cruz LM, Rando-Segura A, Enfedaque B, Riveiro M, Casis E, Ferrer-Costa R, Buti M, Rodriguez-Frias F (2021) Assessing liver fibrosis using the fib4 index in the community setting