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522,523,524 In vitro results demonstrated that mitochondria tend to form smaller and more fragmented ones in breast cancer cells treated with silibinin, indicating altered mitochondrial dynamics

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

Sirtuins as regulators of metabolism and healthspan

Because the results above showed that the reduced dihydrolipoic moiety, but not the oxidized lipoic moiety, can react with RNS, we also included different combinations of substrates during the incubation to manipulate the redox state of the lipoic arm