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906, pp

GPX8 is similar to GPX7 because both have low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH

This implies that androgen activation in PC cells may contribute to mt-DNA mutations and aging-related processes by increasing ROS formation, which can damage DNA and perhaps influence the mutation rate in cells, including PC cells

Two days after transfection, half of the samples were collected for Western blot analysis of CHAC1 expression and the other half for glutathione assay