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The long-term effects can be partially predicted depending on the type of exposure, such as industrial pollutants [2,3] (e.g., diesel fumes), chemicals and toxic gases [35] (e.g., chlorine and mustard gas), occupational exposures [6,7] (e.g., asbestos, coal dust, silica), and recreational products such as tobacco smoke and electronic cigarette vapor [8]

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the subcutaneous, intramuscular, intraarterial and also the oral dosage form is advantageous for long-term treatment