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These oxidatively modified proteins can acquire neoantigen properties - meaning the immune system no longer recognizes them as "self" and mounts an antibody response against them

Once translocated into systemic circulation, LPS activates toll-like receptor 4 (TLR4), triggering NF-B-mediated release of proinflammatory cytokines ( e.g ., TNF-, IL-6) and further aggravating insulin resistance and ovarian inflammation ( Sex hormone metabolism is also modulated by the gut microbiota

A liposome is a microscopic "bubble" or vesicle made from phospholipidsthe same fats that make up our own cell membranes

The invasiveness of the procedures, the complexity and the costs for their in vitro maintenance make them suitable limitedly for validation procedures