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Disrupted brain stem The brain stem, the oldest part of our brain, is responsible for basic functions such as body temperature, sleepwake rhythm, heart rate, breathing, blood pressure, digestion, eye movements, urination, hearing, tasting, chewing, swallowing, and feeling movement and gravity

doi: 10.3389/or.2025.1607983 Received 08 April 2025 Accepted 11 July 2025 Published 21 July 2025 Volume 19 - 2025 Edited by Zhenyi An, Broad Institute, United States Reviewed by Yang Zhu, National University of Singapore, Singapore Charlett Giuliani, Victoria University, Australia Updates Copyright 2025 Yan, Ding, Ren and Zang

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The age-related decline in cellular respiration further exacerbates mitochondrial electron leakage and ROS production, thereby intensifying intracellular oxidative stress