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Consequently, mitophagy is primarily regulated indirectly in PDAC by targeting factors such as mitochondrial integrity, mitochondrial dynamics, autophagosome formation, and autolysosome formation [16] (Fig

2017 Sep 15;96(6):384-389.

Especially in those who are genetically predisposed, oxidative stress strengthens the relationship between environmental factors and the early stages of autoimmune condition

In addition to the aforementioned mechanisms, other mechanisms like protease/antiprotease imbalance, mucus hypersecretion, and cellular senescence also play significant roles in the pathogenesis and progression of COPD