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The evolution of metazoan TrxRs from Gsr involved acquisition of a carboxy (C)-terminal extension to the enzyme that encodes the active site responsible for reducing Trx-disulfides [48, 51, 54]

sclerotiorum needs to secrete oxalic acid (OA) and effectors to counteract plant immunity and ensure pathogen success 31,32,33,34

Cwynar A, Olszewska-Sonina D, Czajkowski R et al (2018) Investigation of oxidative stress in patients with alopecia areata by measuring the levels of malondialdehyde and ceruloplasmin in the blood

Not all conditional GPX4 mouse models produce spontaneous disease phenotypes on a normal diet, although a vitamin E-depleted diet accelerates the pathogenic phenotype of cell death [31]