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Mice obtain breeding The wild-type (WT) C57BL/6 mice were obtained from Beijing Viton Lihua Laboratory Animal Technology Co Ltd, and APP/PS1 double transgenic (2 Tg) mice were obtained from Hangzhou Ziyuan Laboratory Animal Technology Co Ltd

Histone post-translational modifications Histone acetylation and deacetylation Histone acetylation, a sophisticated epigenetic modification, plays a vital physiological role in the regulation of gene transcription by modulating the chromatin structure