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FIGURE 5 3.5 Overcoming delivery barriers with advanced therapeutic systems A significant challenge contributing to the unmet promise of many promising preclinical antioxidant and other oxidative stress-modulating agents is the inefficient and non-targeted delivery of these compounds to the injured myocardium (Borrelli et al., 2021)

Improved sirtuin activation: NAD+ activates sirtuins (longevity enzymes) while glutathione protects sirtuins from oxidative inactivationmaximizing their anti-aging effects

The concentration of GSH-conjugates was 0.2 to 4% of the initial AQ-QI concentration and 0.05 to 0.9% of the DEAQ-QI concentration ( Figure 5A )

An antioxidant found in plants, fungi and other organisms, glutathione helps prevent cell damage caused by free radicals and peroxides