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One option your clinician can walk you through is hormone therapy, as both progesterone and estrogen are helpful to many women in midlife with sleep issues

NNMT isn't the only methyltransferase in the body, and chronic inhibition could theoretically disrupt other one-carbon metabolism pathways

The term aryl refers to an aromatic group having at least one carbocyclic aromatic group or heterocyclic aromatic group, which may be unsubstituted or substituted by one or more groups selected from halogen, haloalkyl, hydroxy, alkoxy, carbonyl, alkylamido, nitro, amino, dialkylamino, carboxy, thio or thioalkyl