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A previous animal study was consistent with this

A.BecanaM

Appl Microbiol Biotechnol (2013) 97(10):432532

291 Hypoxia plays a pivotal role in CSC maintenance and therapy resistance by stabilizing hypoxia-inducible factors (HIF-1 and HIF-2), which activate signaling pathways involved in stemness, metabolic reprogramming, EMT, and DNA repair