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Adverse effects of biologic drugs More common side effects include: a higher risk of respiratory or urinary tract infections headaches flu-like symptoms, such as low energy and body aches reactions at the injection site, such as discoloration, swelling, or discomfort Rarer side effects include: blood disorders a higher risk of certain cancer types an increased risk of serious nervous system disorders, including multiple sclerosis (MS), nervous system inflammation, and seizures Adverse effects of methotrexate Methotrexate is not a biologic drug, and it has different side effects

It lowers blood pressure and cholesterol levels, both of which are crucial factors for heart health

For baseline protocols in untrained subjects, it's overkill