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second, the optimal conditions which were identified during the EP screen for producing DE were the conditions that yielded the most functional and robust hepatic phenotype

The brain substantia nigra in PD has a high level of expression of the VD metabolizing enzyme and 1 hydroxylase, and VD can stimulate the expression of tyrosine hydroxylase, a key enzyme of dopamine synthesis in PD, which affects the production and turnover of dopamine, therefore, the role of VD in the development process of PD has received increasing attention (85, 86)

J Cell Mol Med 21(4):648657 Endale HT, Tesfaye W, Mengstie TA (2023) ROS induced lipid peroxidation and their role in ferroptosis

Furthermore, as a cyto-protectant, melatonin helps alleviate several COVID-19 comorbidities, including T2DM, metabolic syndromes, and both ischemic as well as non-ischemic CVD 657