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Description

Pyridoxine has a history of successful use, at doses ranging from 50 to 800 mg per day, for the prevention and treatment of HFS caused by sorafenib (Nexavar), doxorubicin, 5-FU, docetaxel, or etoposide

The FDA classified Epitalon as a Category 2 bulk drug substance under Section 503A guidance in September 2023, confirmed in September 2024

Recommended use: Take one tablet daily on an empty stomach, with a Vitamin C source for enhanced results

However, this is an increasingly active field of investigation, with numerous topical and systemic therapies currently in phase 2 and 3 trials specifically for CHE [73]