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How acetaminophen is metabolized in the liver Zonation of drug conjugation metabolism in vitro. (a) Acetaminophen Download Scientific Diagram A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC
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