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In the first case, the inability to hydroxylate lysine residues precludes normal intermolecular cross-linking of collagen trimers, and in the second instance, absence of procollagen peptidase prevents normal proteolytic cleavage of the NH 2 -terminus of procollagen chains

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But your digestive system destroys a large portion of those nutrients before they ever reach your bloodstream

This cascade ultimately leads to renal fibrosis, marked by myofibroblast proliferation, excessive extracellular matrix deposition, glomerulosclerosis, tubular atrophy, and microvascular rarefaction, resulting in irreversible nephron loss and a decline in renal function toward end-stage renal disease