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As such, the first three PCs explained 62% of the variance of the original data set, with PC1 describing 41%, PC2 describing 13%, and PC3 describing 8% of the total variance, with principal component analysis (PCA) clearly dividing cells into four different clusters matching their groups (Figure 2C)

Advanced minimally invasive approaches such as robotic laparoscopy have further enhanced surgical precision and anatomical visualization, reducing postoperative complications and recovery time while effectively removing complex deep endometriosis lesions with preserved fertility potential ( Discoid excision, a conservative surgical technique, is particularly relevant for managing colorectal deep endometriosis (DE) and has demonstrated favorable fertility outcomes

Despite these promising developments, several critical challenges remain

Cereblon-based PROTACs are considered the most oral drug-like due to their cereblon ligase ligands