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Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety

Vettori S, Cuomo G, Iudici M, DAbrosca V, Giacco V, Barra G, De Palma R, Valentini G (2014) Early systemic sclerosis: serum profiling of factors involved in endothelial, T-cell, and fibroblast interplay is marked by elevated interleukin-33 levels

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