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In the presence of thiol compounds such as glutathione or cysteine, dopaquinone is diverted toward the synthesis of pheomelanin a lighter, yellow-to-reddish pigment instead of the darker, brown-to-black eumelanin that forms when thiols are absent

Exclusion criteria comprised studies lacking relevance to depressive disorders, investigations focused solely on unrelated neurological or systemic conditions, reports involving non-standardized or poorly characterized herbal preparations, and articles without sufficient methodological or outcome detail

Pregnancy Category: Consult a doctor before use during pregnancy or breastfeeding

Genetic Variants and Methylation Dysfunction S