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Cell-microbe and host-derived double-stranded DNA (dsDNA) can be sensed and regulated for defense against extracellular or intracellular infection (Hopfner and Hornung, Studies have revealed an association between the cGAS-STING process and ferroptosis

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ACSL4 promotes the integration of PUFA into membrane phospholipids by catalyzing the esterification of PUFA to generate PUFA-CoA, making CD8+ T cells 23 times more sensitive to GPX4 inhibitors (152)