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Additionally, in mice with experimental tubulointerstitial nephritis, renoprotection was observed in conjunction with a reduction in the expression of inflammatory molecules when allopurinol or the blockade of genes linked to the NLRP3 inflammasome response (apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain [CARD] (ASC) and caspase 1) was administered (126)

Sin su funcin los cuerpos grasos se acumularan en los tejidos muscular y adiposo as como en las arterias

doi: 10.2741/1826

In the 1980s, it was found that supplementation with sodium selenite could improve chondrodystrophy (Kashin-Beck disease) and juvenile cardiomyopathy (Keshan disease) which were caused by Se deficiency