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This is by far the most accurate model because the same cell line from a single patient has the potential to be differentiated into any cell type to study the effects of pathogenic mutations on the different cells and tissues in humans

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Methods Patients and tumor samples After obtaining written informed consent, surgical specimens and clinical records were obtained from 16 patients with gliomas who had surgery to remove brain tumors at the First Affiliated Hospital of Chongqing Medical University (Chongqing, China), in accordance with the appropriate Institutional Review Boards (Table 1)

Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorderscurrent evidence and preliminary recommendations