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however, the IC50 of the remaining compounds cannot be determined as they showed inhibitory activity lower than 50% at 50M, as shown in Fig

Richards, C

Alterations in proteostasis system components in peripheral blood mononuclear cells in Parkinson disease: focusing on the HSP70 and p62 levels

Studies demonstrate that the intracellular portion of CFTR binds to protein modules referred to as PSD-95/Discs-large/ZO-1 (PDZ) domains, which promote proteinprotein interactions