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Approximately 30% of patients achieve a partial remission with doxorubicin.[4] The combination of doxorubicin plus cisplatin appears to be more active than doxorubicin alone and has produced more complete responses.[5] The combination of chemotherapy plus radiation therapy after complete resection may provide prolonged survival in some patients, but this treatment combination has not been compared with any one modality alone.[6,7] An estimated 25% of patients with anaplastic thyroid cancers have an activating BRAF V600E variant.[8] Evidence (dabrafenib and trametinib): A phase II trial of BRAF and MEK inhibitors, dabrafenib and trametinib, included 16 patients with anaplastic thyroid cancer and a BRAF V600E variant.[9][Level of evidence C2] The confirmed overall response rate was 69%

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Available online at: 121 KivimkiM.BattyG