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Thereafter, anhydrous magnesium sulfate (MgSO ) was added to ethyl acetate to remove moisture, followed by distillation under reduced pressure to remove ethyl acetate, thus obtaining 12 g of ethyl (R)-4-chloro-3-hydroxybutyrate

[Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ observed by mass spectrometry was not detected by 195 Pt NMR, presumably because of detection sensitivities and the low concentration of [Pt(NH 3 ) 2 (H 2 O) 2 ] 2+ .From these results, It was confirmed that chloride in cisplatin was exchanged not for TMG but for water in the 50 wt% TMG aq