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3.3 DARA treatment lowers ADO and elevates INO to concentrations within the receptor-activating range in MM patients To determine whether the in vitro findings translate to the clinical setting, we next quantified ADO and INO levels in paired BM and PB samples collected from 7 MM patients treated with DARA monotherapy ( Table 1 )

Finally, management of couples with affected male partners should also include psychosocial and genetic support

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The extended halflife of approximately 7 days is due to albumin binding and resistance to DPP4 degradation, enabling convenient onceweekly dosing [1]