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Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of rapamycin signaling pathway
This leads researchers to assume that there is a heritable component to mastocytosis as well (e.g., other genes involved).[ref][ref] In addition to KIT mutations, systemic mastocytosis also has links to mutations in the JAK2, PDGFR, NRAS, RASGRP4, CBL, IL4, TET2, and IL13 genes.[ref] MicroRNAs are also involved in the regulation of KIT expression.[ref] Interestingly, about half of all kids with cutaneous mastocytosis tend to outgrow it and go into long-term remission
The GAG composition is altered, reducing hydration and resilience
