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In fact, this link is so compelling that many researchers have referred to Alzheimer disease as type 3 diabetes (Ahmed 2015

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In retina and optic nerve, TNF is rapidly release from glial cells (i.e., microglia, Mller cells) as a response to cell-stress inducing factors, like increased intraocular pressure ( 2+ permeability of AMPA receptor (AMPAR) and accumulation of Ca 2+ in cytosol, mitochondrial damage and ROS production (Tezel, 2008)

In addition to a compatible osmolyte, proline serves as a potent scavenger of ROS and regulates the functioning of antioxidative enzymes by maintaining the NADP + / NADPH ratio