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Furthermore, increased peroxynitrite may also contribute to cytokine-induced cardiac contractile failure by inactivating sarcoplasmic Ca 2+ -ATPase and disrupting Ca 2+ homeostasis [161]

ACS Appl Mater Interfaces 2020;12:11397408

In this field, the main challenges are represented by data quality management, standardization of statistical models, and normalization methods across different pipelines and, ultimately, the biological interpretation and validation of findings