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Hunot S, Dugas N, Faucheux B, Hartmann A, Tardieu M, Debr P, Agid Y, Dugas B, Hirsch EC

ER/ER ratio and aromatase expression levels as well as 2-hydroxyestrone:16-hydroxyestrone ratios are becoming used as biomarkers to direct phytoestrogen or DIM (diindolylmethane) supplementation, whereas the NF-B, STAT3 and PI3K/Akt phosphorylation status potentially indicating curcumin, resveratrol or polyphenols use for chemosensitizing

Any of these protocols should be clinician-directed, with baseline labs, a compliant compounding pharmacy, and a clear plan for how youll evaluate response at the 3-month mark